Transnational organized crime (TOC) is a widespread phenomenon that leaves no region untouched. Illegal trafficking—TOC’s most lucrative manifestation—has taken multiple forms, ranging from the most traditional trade in narcotics and weapons to smuggling counterfeited medicines and endangered wildlife. As these illicit flows cut across multiple national borders, they become interconnected with local security, political, social, and economic dynamics. At times, they are so embedded that the line between licit and illicit is significantly blurred. The same applies when TOC intersects with conflict situations.